目的探讨优化妊娠合并急性阑尾炎(AAP)围手术期的药物治疗方法。方法回顾分析2009年3月—2012年5月期间手术治疗的35例AAP患者,总结其围手术期治疗特点及模式,观察随访治疗效果及妊娠结局。结果 3例要求终止妊娠。先兆流产1例,先兆早产4例,1例胎儿死亡,胎儿丢失率3.1%(1/32)。全部病例均随访至胎儿分娩后1月,未见出生畸形,无喂养困难、排便异常及神经系统异常反应。结论及早手术、监测降钙素原使用抗生素、调控炎症反应、营养支持等围手术期治疗模式对AAP患者避免胎儿丢失、保障母婴安全具有重要的临床意义。 Objective To investigate the perioperative pharmacotherapy for the treatment of acute appendicitis complicated with pregnancy (AAP). Methods A retrospective analysis was performed on 35 patients with AAP who underwent surgery between March 2009 and May 2012. The characteristics and patterns of perioperative treatment were summarized. The follow-up treatment effect and pregnancy outcome were observed. Results 3 cases required termination of pregnancy. Threatened abortion in 1 case, threatened preterm labor in 4 cases, 1 case of fetal death, fetal loss rate of 3.1% (1/32). All cases were followed up to January after birth, no birth deformity, no feeding difficulties, defecation abnormalities and nervous system abnormal reaction. CONCLUSIONS: Early treatment, monitoring of procalcitonin using antibiotics, regulating inflammatory response, nutritional support and other perioperative modes of treatment are of great clinical significance in avoiding fetal loss and ensuring the safety of mother and baby.