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作者在卢旺达进行了麻疹减毒活疫苗对患儿和健康儿童的免疫原性和安全性的前瞻性比较研究。研究对象为518名8～19月龄儿童,其中患儿267例,健康儿童251名。每人接种1剂Schwarz株麻疹减毒活疫苗。观察接种反应,并于接种前和接种后40天分别采血,用酶免疫试验检测麻疹抗体水平。结果表明,15%免疫后有轻微反应,其中84%发生于免疫后5～12天,主要表现为发热、皮疹和Koplik斑,少数人在免疫后3～5天出现短暂的腹泻和咳嗽,未出现神经
The authors conducted a prospective, comparative study of the immunogenicity and safety of live attenuated measles vaccine in children and healthy children in Rwanda. The subjects were 518 children aged 8-19 months, of whom 267 were children and 251 were healthy children. One dose of Schwarz measles live attenuated vaccine per person. The inoculation reaction was observed. Blood samples were taken before inoculation and 40 days after inoculation, respectively, and the level of measles antibody was detected by enzyme immunoassay. The results showed that there was a slight reaction after 15% immunization, of which 84% occurred 5 to 12 days after immunization, mainly showing fever, skin rash and Koplik plaque. Few people experienced transient diarrhea and cough 3 to 5 days after immunization. Nerves appear