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目的通过检测肺癌患者血液中C-反应蛋白(CRP)、纤维蛋白原(FIB)以及血小板(PLT)水平,研究其在肺癌患者术后疗效中的临床意义。方法总结本院自2007年-2013年收治的196例肺癌患者的CRP、FIB和PLT水平,对病理类型、肿瘤转移及胸腔积液等进行回顾性分析。结果不同性别、年龄、吸烟史、病理类型肺癌患者PLT、FIB与CRP含量差异均无统计学意义(P>0.05)。PLT水平在脑转移组中升高,FIB水平在肝转移组中升高,CRP水平在肝转移组、肾上腺转移组、骨转移组中升高,差异均有统计学意义(P<0.05)。有胸腔积液组中PLT、FIB和CRP水平升高,差异均有统计学意义(P<0.05)。结论联合检测CRP、FIB和PLT能够作为肺癌患者预后有无转移及胸腔积液等的警示指标。
Objective To investigate the clinical significance of postoperative curative effect of lung cancer patients by detecting the levels of C-reactive protein (CRP), fibrinogen (FIB) and platelet (PLT) in patients with lung cancer. Methods The CRP, FIB and PLT levels in 196 patients with lung cancer admitted to our hospital from 2007 to 2013 were analyzed retrospectively. The pathological types, tumor metastasis and pleural effusion were retrospectively analyzed. Results There were no significant differences in PLT, FIB and CRP levels between different sexes, ages, smoking history and pathological types of lung cancer (P> 0.05). PLT levels increased in brain metastases group, FIB levels increased in liver metastases group, CRP levels increased in liver metastasis group, adrenal metastasis group and bone metastasis group (all P <0.05). Pleural effusion group PLT, FIB and CRP levels increased, the differences were statistically significant (P <0.05). Conclusion Combined detection of CRP, FIB and PLT can be used as a marker of prognosis of patients with lung cancer metastasis and pleural effusion.