相隔24小时给兔作2次静脉注射内毒素,结果出现休克,并造成肾皮质坏死和多脏器的损害灶,这种现象称Shwartzman反应。人类疾病中亦存在类似情况。革兰氏阴性菌败血症或内毒素血症通常引起这种反应,并可导致急性肾衰。每个革兰氏阴性细菌有一层外衣,它是由750,000个脂多糖分子(即内毒素)所组 Twenty-four hours apart, intravenous injection of endotoxin into the rabbit resulted in shock and necrosis of the renal cortex and multiple organ damage, a phenomenon known as the Shwartzman response. A similar situation exists in human diseases. Gram-negative sepsis or endotoxemia usually causes this reaction and can lead to acute renal failure. Each Gram-negative bacterium has a coat that consists of 750,000 lipopolysaccharide molecules (ie, endotoxins)