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目的研究单纯的慢性支气管炎和煤工尘肺合并慢性支气管炎患者的ＨＬＡＤＲＢ１等位基因的异同。方法采用顺序特异性引物聚合酶链反应技术，检测了山西省汉族的３７例单纯慢性支气管炎和３３例煤工尘肺合并慢性支气管炎患者的ＨＬＡＤＲＢ１等位基因频率，并与山西省正常人群进行比较分析。结果单纯慢性支气管炎组的ＨＬＡＤＲＢ１１２０Ｘ基因频率明显增高（２４．３％），而煤工尘肺合并慢性支气管炎组的ＨＬＡＤＲＢ１０４０Ｘ基因频率明显增高（２２．７％），其他等位基因频率在３组之间差异无显著性。结论在山西省汉族人群中，ＨＬＡＤＲＢ１１２０Ｘ与单纯慢性支气管炎有关联，而ＨＬＡＤＲＢ１０４０Ｘ与煤工尘肺合并慢性支气管炎有关联
Objective To study the similarities and differences between HLA-DRB1 alleles and pure chronic bronchitis and coal worker pneumoconiosis patients with chronic bronchitis. Methods Using sequence-specific primer polymerase chain reaction (PCR), the frequencies of HLA-DRB1 alleles in 37 patients with chronic bronchitis and 33 coal workers with pneumoconiosis and chronic bronchitis in Shanxi Han were detected and compared with those in Shanxi Province For comparative analysis. Results The frequency of HLA-DRB1 * 120X gene in chronic bronchitis group was significantly higher than that in chronic bronchitis group (24.3%), while the frequency of HLA-DRB1 * 040X gene in coal worker’s pneumoconiosis and chronic bronchitis group was significantly increased (22.7%). Other There was no significant difference in allele frequencies among the three groups. Conclusion HLA-DRB1 * 120X is associated with chronic bronchitis in Han Chinese population in Shanxi Province, while HLA-DRB1 * 040X is associated with pneumoconiosis and chronic bronchitis