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microRNA(miRNA)是一类进化上高度保守的转录后调控因子,其参与基因表达调控,对细胞的分化、增殖和调亡有重要影响。近年来,越来越多的研究发现许多肿瘤的发生与miRNA密切相关。单核苷酸多态性(single nucleotide polymorphism,SNP)对miRNA的合成及其与靶基因的结合有调节作用,也是导致不同种族个体对于疾病的易感性和不同药物反应性不同的原因之一。胃癌和食管癌是2种常见的上消化道肿瘤。本文主要对miRNA相关SNP与这2种
MicroRNAs (miRNAs) are a class of evolutionarily highly conserved post-transcriptional regulators involved in the regulation of gene expression and have important implications for the differentiation, proliferation and apoptosis of cells. In recent years, more and more studies have found that many tumors are closely related to miRNA. Single nucleotide polymorphisms (SNPs) play a regulatory role in the synthesis of miRNAs and their binding to target genes, and are also one of the reasons leading to different susceptibility to disease and different drug reactivity in individuals of different races. Gastric cancer and esophageal cancer are two common upper gastrointestinal tumors. This article focuses on miRNA-related SNPs with these two species