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药源性头痛系指药物直接或间接引发的头痛,约占全部头痛患者的5%～10%。药源性头痛发生的机制尚不清楚,其发生的常见原因如下:血管扩张、良性颅内压增高、无菌性脑膜炎、双硫仑样反应以及过度使用镇痛药。药源性头痛的临床表现,除有头痛症状外,也可伴有头晕、恶心、呕吐、面部潮红、血压下降等。常见的致病药物有非甾体抗炎药、组胺H2受体拮抗剂、钙离子拮抗剂及血管扩张剂。药物治疗中出现头痛应注意将其与原发病所致头痛相区别。及时停药和对症处理可缓解药源性头痛症状。
Drug-induced headache refers to drugs directly or indirectly caused by headache, accounting for about 5% to 10% of all headache patients. The mechanism by which drug-induced headache occurs is not clear, and common causes of it are as follows: vasodilation, increased benign intracranial pressure, aseptic meningitis, disulfiram-like response, and overuse of analgesics. Drug-induced headache clinical manifestations, in addition to headache symptoms, but also may be associated with dizziness, nausea, vomiting, facial flushing, blood pressure and so on. Common pathogenic drugs are non-steroidal anti-inflammatory drugs, histamine H2 receptor antagonists, calcium antagonists and vasodilators. Headache in drug treatment should pay attention to the headache caused by the original disease are different. Timely withdrawal and symptomatic treatment can ease the symptoms of drug-induced headache.