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目的比较传统MRI阳性EV71脑炎与MRI阴性脑炎患者临床特征。方法选取21位传统MRI阴性的EV71患儿与11位MRI阳性的EV71脑炎患儿,所有患儿进行传统的MRI检查(T1WI、T2WI、FLAIR),并根据检查结果将患儿分为MRI阳性组及MRI阴性组,比较两组临床特征。结果 MRI阴性组的临床特征,包括年龄、性别、高热、皮疹、肢体震颤、头痛、呕吐、心率加快、呼吸加快、高血压、意识障碍、肢体无力、眼球运动异常、肺出血、血糖、血白细胞计数、CSF压力、CSF细胞数、CSF总蛋白与MRI阳性组比较,无统计学差异。结论传统MRI阳性的EV71脑炎患儿,并不代表其临床特征更差。为了识别更加严重的EV71脑炎,可能需要行增强MRI或弥散-加权成像的MRI。
Objective To compare the clinical features of patients with MRI-positive EV71 encephalitis and MRI-negative encephalitis. Methods Totally 21 children with EV71-negative EV71 and 11 children with EV71-positive encephalitis were enrolled in this study. All children underwent conventional MRI (T1WI, T2WI, FLAIR). According to the results, the children were divided into MRI positive Group and MRI-negative group, the clinical features of two groups were compared. Results The clinical features of the MRI negative group included age, gender, fever, rash, limb tremor, headache, vomiting, accelerated heart rate, accelerated breathing, hypertension, disturbance of consciousness, limb weakness, abnormal eye movement, pulmonary hemorrhage, There was no significant difference in counting, CSF pressure, CSF cell count, CSF total protein and MRI positive group. CONCLUSIONS: Children with EV71-positive encephalitis do not represent worse clinical features. In order to identify the more severe EV71 encephalitis, MRI with enhanced MRI or diffusion-weighted imaging may be required.