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目的探讨血液灌流联合血液透析在重度急性有机磷中毒患者治疗中的应用效果。方法选取2013年4月至2014年5月重度急性有机磷中毒患者112例作为研究对象,使用随机数字表法将其分为观察组和对照组,每组56例。对照组给予常规治疗,观察组在对照组治疗的基础上给予血液灌流联合血液透析治疗,比较两组患者的治疗效果。结果观察组阿托品用量、胆碱酯酶活性恢复时间、清醒时间以及住院时间等均少于对照组,差异有统计学意义(P<0.05)。观察组死亡1例,病死率为1.8%;对照组死亡4例,病死率为7.1%,观察组病死率明显低于对照组,差异有统计学意义(P<0.05)。结论血液灌流联合血液透析在重度急性有机磷中毒患者的治疗中有着良好的临床效果,能够有效缩短患者昏迷时间、住院时间以及胆碱酯酶活动性恢复时间,同时有效降低患者阿托品用量以及病死率,对患者快速康复有着重要意义。
Objective To investigate the effect of hemoperfusion combined with hemodialysis in the treatment of patients with severe acute organophosphate poisoning. Methods A total of 112 patients with severe acute organophosphorus poisoning from April 2013 to May 2014 were selected as study subjects and divided into observation group and control group using random number table method, with 56 cases in each group. The control group was given routine treatment. The observation group was given hemoperfusion combined with hemodialysis on the basis of the control group, and the treatment effect was compared between the two groups. Results The amount of atropine in the observation group, recovery time of cholinesterase activity, awake time and hospitalization time were less than the control group, the difference was statistically significant (P <0.05). In the observation group, 1 patient died and the case fatality rate was 1.8%. In the control group, 4 patients died and the case fatality rate was 7.1%. The case fatality rate in the observation group was significantly lower than that in the control group (P <0.05). Conclusion Hemoperfusion combined with hemodialysis has a good clinical effect in the treatment of patients with severe acute organophosphorus poisoning, which can effectively shorten the coma time, length of hospital stay and recovery time of cholinesterase activity, and at the same time effectively reduce the amount of patients with atropine and mortality , Rapid recovery of patients is of great significance.