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作者报道老年多器官功能衰竭(MOF)患者23例在衰竭前后T,B淋巴细胞及其亚群、免疫球蛋白及补体的变化.结果表明:MOF患者CD3_,CD_4,CD_8,CD_4/CD_8,CD_(20)及Sm IgG阳性细胞均比对照组少,随病情发展,死亡组CD_3,CD_4,CD_(20),Sm IgG细胞持续减少,而存活组CD_3,CD_4细胞呈上升趋势;死亡组血清IgG水平进行性下降,存活组仅轻度下降;患者组补体C_3明显低于对照组,随病情发展,C_3含量进一步减少,但死亡组与存活组间无差异(P>0.05).结果提示:免疫系统的功能状态与老年人MOF的预后有关.
The authors reported the changes of T, B lymphocytes and their subsets, immunoglobulin and complement in 23 patients with multiple organ failure (MOF) before and after failure.The results showed that the expressions of CD3, CD_4, CD_8, CD_4 / CD_8, (20) and Sm IgG positive cells were lower than those in control group. With the progression of disease, the number of CD_3, CD_4, CD_ (20) and Sm IgG in death group continued to decrease, but the survival rate of CD_3 and CD_4 cells in surviving group increased. (P <0.05) .Conclusion: The level of C_3 in complement is significantly lower than that in control group, and the level of C_3 is further decreased with the progression of disease, but there is no difference between death group and survival group The functional status of the system is related to the prognosis of the elderly with MOF.