本实验对9名3～50岁智力低下、有脆性X染色体综合征的男患进行了研究。所有儿童都不符合婴儿孤癖症的诊断标准,但其中几个表现出性情孤癖、注意力不集中和好动。所有的孩子都有明显的语言障碍和行动迟钝,其中三例有明显的肌肉张力减退。患者按每日每公斤体重0.5～2mg口服叶酸,持续3～18个月。 In this study, 9 male patients aged 3 ~ 50 with mental retardation and Fragile X syndrome were studied. None of the children meet the diagnostic criteria for infantile adrenal disease, but several of them show solitary addiction, poor concentration and hyperactivity. All children had significant speech impairment and immobility, and three of them had significant muscle tone loss. Patients per day per kilogram of body weight 0.5 ~ 2mg oral folic acid for 3 to 18 months.