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Objective:To explore the expression ofAnnexinⅡ and its relationship with the cell differentiation, proliferation in lung cancer.Methods:RT-PCR andWest blot assays were used to detect the expression ofAnnexinⅡ in lung cancer tissues and cell lines.Results:AnnexinⅡwas significantly up-regulated in lung cancer tissues, and in lung cancer cell lines, Annexin Ⅱ had higher mRNA and protein expressions.Conclusions:AnnexinⅡis up-regulated in lung cancer, suggesting that theAnnexinⅡhas a potential value in the human lung cancer.