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用测定气流阻滞而非炎症的试验评估哮喘治疗的效果。哮喘患者的气道表皮细胞中可诱发的氧化氮合成酶增加,哮喘呼出物中的一氧化氮(NO)浓度随抗炎治疗进行而下降。然而,使用NO测定纵向评估气道炎症一直受多种技术的限制。作者假设:稳态水相氧化氮(NOx)可比反应的NO测定更方便,且在哮喘患者的冷凝呼出物中浓度更高。 检查无肺疾病或气流阻滞史的志愿者作对照,并
The effect of asthma treatment was assessed using a test that measures airflow arrest rather than inflammation. In patients with asthma, airway epithelial cells induce an increased nitric oxide synthase (NO) concentration in asthmatic exhaled airways with decreasing anti-inflammatory treatment. However, longitudinal assessment of airway inflammation using NO assays has been limited by many techniques. The authors hypothesize that steady-state aqueous nitric oxide (NOx) may be more convenient than NO determination of response and may be found at higher concentrations in the condensed breath of asthmatic patients. Check the volunteers without history of lung disease or airflow block as control