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目的:探讨前列地尔治疗糖尿病肾病的临床效果及对血清炎症因子、肾脏纤维化指标的影响。方法:选取2015年6月至2016年6月在本院接受治疗的糖尿病肾病患者120例,根据就诊单双号分为前列地尔组、常规组各60例,两组均行常规治疗,前列地尔组同时给予前列地尔治疗,对比两组治疗效果。结果:治疗前、后两组的空腹血糖、SBP、DBP水平比较差异均无无统计学意义(P>0.05)。治疗前两组的尿素氮、血肌酐(Scr)、尿微量白蛋白(UAER)、β2-微球蛋白(β2-MG)水平比较差异均无统计学意义(P>0.05);治疗后前列地尔组的Scr、UAER、β2-MG均低于常规组(P<0.05);治疗前两组的白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平比较差异均无统计学意义(P>0.05);治疗后前列地尔组的IL-6、TNF-α水平均低于常规组(P<0.05);治疗前两组的血浆层黏蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(CⅣ)水平比较差异均无统计学意义(P>0.05);治疗后前列地尔组的血浆LN、PCⅢ、CⅣ水平均低于常规组(P<0.05)。结论:前列地尔治疗糖尿病肾病患者可以显著改善肾功能,降低血清炎症因子水平及肾脏纤维化指标。
Objective: To investigate the clinical effect of alprostadil in the treatment of diabetic nephropathy and its influence on serum inflammatory factors and renal fibrosis indexes. Methods: A total of 120 diabetic nephropathy patients treated in our hospital from June 2015 to June 2016 were selected. Patients were divided into alprostadil group (60 cases) and conventional group (60 cases) Diuretic group were given alprostadil treatment, compared with two groups of treatment. Results: There was no significant difference in fasting blood glucose, SBP and DBP levels between the two groups before and after treatment (P> 0.05). The levels of blood urea nitrogen, serum creatinine (Scr), urine microalbuminuria (UAER) and β2-microglobulin (β2-MG) in the two groups before treatment were not significantly different (P> 0.05) The levels of Scr, UAER and β2-MG in the two groups were lower than those in the conventional group (P <0.05). The levels of IL-6 and TNF-α in the two groups before treatment were significantly different (P> 0.05). After treatment, the levels of IL-6 and TNF-α in the alprostadil group were lower than those in the conventional group (P <0.05). The levels of plasma laminin (LN) There was no significant difference in the levels of PCⅢ and CⅣ between the two groups (P> 0.05). After treatment, the plasma levels of LN, PCⅢ and CⅣ in the alprostadil group were lower than those in the conventional group (P < 0.05). Conclusion: Alprostadil treatment of diabetic nephropathy patients can significantly improve renal function, reduce serum levels of inflammatory cytokines and renal fibrosis indicators.