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白细胞介素 18(IL 18)主要来源于人和鼠的单核细胞和巨噬细胞 ,其前体无生物学活性 ,经过转化酶裂解成为成熟蛋白后才能发挥生物学作用。IL 18的生物学作用主要有诱导T细胞增殖和IFN λ的产生及抗肿瘤作用。NF κB是IL 18重要的信号传导途径。
Interleukin 18 (IL 18) is mainly derived from human and murine monocytes and macrophages. Its precursor has no biological activity and can be biologically effective after it is cleaved by invertase into mature protein. The biological effects of IL 18 mainly induce T cell proliferation and IFN λ production and anti-tumor effect. NF κB is an important signaling pathway for IL 18.