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环丙沙星(CPLX)是合成的第三代喹诺酮类抗菌药物,由于其抗菌谱广、起效迅速、抗菌力强而被广泛应用于各种细菌性感染。随着临床应用的日益广泛,不良反应的发生也在增多。为了引起临床医生的高度重视,本文根据近年来的相继报道作一概述。 1.致精神异常 骆慧玲等报道1例38岁女性患者,无神经精神病史。因流行性出血热住院,因合并尿路感染给予口服环丙沙星,一次0.25g,bid,服药第3d下午开始出现精神症状:患者兴奋,拒绝治疗,要求看书看报,次日因怀疑环内沙星引起而停药,停药第2d上述症状消失。出院后随访得知,患者又曾口服环丙沙星,继而出现精神症状,且更加明显,持续1d后自行好转。
Ciprofloxacin (CPLX) is a synthetic third-generation quinolone antibacterial drug, which is widely used in various bacterial infections due to its broad antibacterial spectrum, rapid onset of action and strong antibacterial activity. With the increasingly wide range of clinical applications, the incidence of adverse reactions are also increasing. In order to arouse the great attention of clinicians, this article gives an overview based on the successive reports in recent years. 1. induced mental abnormalities Luo Huiling and other reports of a 38-year-old female patient, no history of neuropsychiatric disorders. Because of epidemic hemorrhagic fever hospitalized, due to merger urinary tract infection given oral ciprofloxacin, a 0.25g, bid, medication began 3d psychiatric symptoms in the afternoon: patients excited, refused to treat, read a newspaper, the next day due to suspicion ring Neocarpine caused withdrawal, discontinuation of the first 2d of the above symptoms disappear. Follow-up after discharge from the hospital revealed that patients had oral ciprofloxacin, followed by mental symptoms, and more obvious, continued to improve after 1d.