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探讨补阳还五汤对阿尔茨海默病模型小鼠海马神经元细胞凋亡的影响。方法雄性小鼠随机分成对照组、模型组、治疗组(吡拉西坦0.62 g·kg~(-1)·d~(-1))、补阳还五汤高剂量组(37.06 g·kg~(-1)·d~(-1))、补阳还五汤中剂量组(18.53 g·kg~(-1)·d~(-1))、补阳还五汤低剂量组(9.26 g·kg~(-1)·d~(-1)),给药共28 d。应用TUNEL法检测小鼠海马神经元细胞凋亡的变化。结果与模型组组比较,采用TUNEL法染色显示补阳还五汤组小鼠海马神经元阳性细胞数明显降低(P<0.05)。结论补阳还五汤对阿尔茨海默病模型小鼠海马神经元细胞凋亡有抑制作用。
Effect of Buyang Huanwu Decoction on Apoptosis of Hippocampal Neurons in Alzheimer ’s Disease Model Mice. Methods Male mice were randomly divided into control group, model group, treatment group (piracetam 0.62 g · kg -1 · d -1), budesonide high dose group (37.06 g · kg -1) (-1) · d -1), BYHWD medium dose group (18.53 g · kg -1 · d -1), BYHWD low dose group 9.26 g · kg -1 · d -1) for 28 days. Detection of apoptosis in hippocampus neurons by TUNEL method. Results Compared with the model group, TUNEL staining showed that the number of positive cells in the hippocampal neurons of Buyang Huanwu Decoction group was significantly decreased (P <0.05). Conclusion Buyang Huanwu decoction can inhibit the apoptosis of hippocampal neurons in Alzheimer’s disease model mice.