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目的:探讨慢性牙周炎患者血清C反应蛋白(CPR)、E-选择素水平的变化及其临床意义。方法:选择143例慢性牙周炎患者,用免疫比浊法测定血清CPR,用酶联免疫吸附反应法(ELISA)测定血清E选择素水平,并和正常对照组比较。结果:慢性牙周炎患者血清CPR、E选择素水平增高,和牙周正常者比较(P<0.01)。结论:慢性牙周炎患者血清CPR、E-选择素的水平升高,是牙周炎促使冠心病发生发展的的重要物质基础。
Objective: To investigate the changes of serum C-reactive protein (CPR) and E-selectin in patients with chronic periodontitis and its clinical significance. Methods: 143 patients with chronic periodontitis were selected. Serum CPR was measured by immunoturbidimetry. Serum E-selectin level was measured by enzyme-linked immunosorbent assay (ELISA) and compared with normal control group. Results: Serum levels of CPR and E-selectin in patients with chronic periodontitis were significantly higher than those with normal periodontal disease (P <0.01). Conclusion: Serum levels of CPR and E-selectin are elevated in patients with chronic periodontitis, which is an important material basis for periodontitis to promote the development of coronary heart disease.