呼吸道合胞病毒(Respiratory syncytial virus,RSV)属于副黏病毒科肺炎病毒亚科病毒,是一种引起人严重呼吸道疾病的病原体,主要感染婴幼儿、老年人及免疫缺陷的成年人。病毒合胞体的形成是RSV感染细胞导致细胞病变的最主要特征。有研究表明,RSV的受体黏合和促融合活力主要依赖2个不同的刺突结构,分别是吸附(G)糖蛋白和融合(F)糖蛋白,G糖蛋白的主要作用是促进RSV与靶细胞的吸附,而F糖蛋白的主要作用是促进病毒与细胞、细胞与细胞之间的融合。本文就近几年RSV合胞体形成机制的研究进展作一综述。 Respiratory syncytial virus (RSV) belongs to the Paramyxoviridae pneumonia virus subfamily. It is a causative agent of severe respiratory diseases and mainly infects infants and young children, the elderly and immunocompromised adults. The formation of virus syncytia is the most important feature of RSV infected cells leading to cytopathic effect. It has been shown that the receptor binding and pro-fusion activity of RSV relies mainly on two different spike structures, namely the adsorbed (G) glycoprotein and the fused (F) glycoprotein whose primary role is to promote RSV interaction with the target Cell adsorption, while the main role of F glycoprotein is to promote the fusion of virus and cell, cell and cell. This review summarizes the research progress of RSV syncytium formation in recent years.