目的:精氨酸是一种可以调节肿瘤生长的非必需氨基酸,精氨基琥珀酸合成酶是精氨酸从头生成的限速酶。精氨基琥珀酸合成酶的表达模式和精氨酸剥夺疗法在头颈肿瘤治疗的可行性还没有研究。材料和方法:评估精氨酸剥夺疗法的生长抑制作用,通过在无 Purpose: Arginine is a nonessential amino acid that regulates tumor growth. Argininosuccinate synthase is the rate-limiting enzyme for de novo arginine production. The feasibility of arginine succinate synthase expression and arginine deprivation in the treatment of head and neck cancer has not been studied. Materials and Methods: To assess the growth inhibitory effect of arginine deprivation therapy through the absence of