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目的探讨癫发作和抗癫药物治疗对催乳素(PRL)分泌的影响。方法采用放射免疫法(RIA)检测49例患儿癫发作期间及抗癫药物治疗后血清PRL水平。结果癫发作后血清PRL水平要较正常对照组明显升高;癫发作类型和血清PRL水平升高之间具有明显的相关性;各种抗癫药物对血清PRL水平的影响不同。结论癫发作和抗癫药物治疗均明显影响垂体PRL的分泌功能。
Objective To investigate the effects of epileptic seizures and antiepileptic drugs on prolactin (PRL) secretion. Methods Radioimmunoassay (RIA) was used to detect serum PRL levels in 49 children with epileptic seizures and antiepileptic drugs. Results Serum PRL levels increased significantly after epileptic seizures than those in normal controls. There was a significant correlation between seizure types and serum PRL levels. The effects of various antiepileptic drugs on serum PRL levels were different. Conclusion Epileptic seizures and antiepileptic drugs significantly affect the secretion of pituitary PRL.