新生儿缺氧缺血性脑病(HIE)在发达国家的发病率为(1~2)/1000,而在发展中国家更为常见,全世界每年400万的新生儿死亡病例中99%发生在发展中国家,1/4与围产期窒息有关,其发病机制复杂,常引起新生儿死亡,存活者往往留有不同程度的脑损害。发达国家已将亚低温作为治疗新生儿HIE的常规治疗方法。随着对HIE病理生理及亚低温的神经保护机制的不断深入研究以及临床经验的积累,鼓励发展 The incidence of neonatal hypoxic-ischemic encephalopathy (HIE) in developed countries is (1-2) / 1000 and more common in developing countries, with 99% of all neonatal deaths occurring annually in the world at 4 million Developing countries, 1/4 and perinatal asphyxia, its pathogenesis is complicated, often cause newborns to die, survivors often have varying degrees of brain damage. Developed countries have hypothermia as a routine treatment for neonatal HIE. With the HIE pathophysiology and mild hypothermia neuroprotective mechanisms continue to deepen the study and the accumulation of clinical experience to encourage the development