传统方法观察大鼠血流动力学指标需将动物麻醉或制动,而麻醉剂或制动引起的应激对动物心血管功能影响甚大。在大鼠清醒自由活动情况下监测动脉血压、心率已有报道。但达些研究中给药均通过静脉途径。本实验改进了胃内给药方法,采用胃瘘管内注药,能够直接观察胃内给药后短期内血流动力学变化。在此基础上我们观察了尼群地平与阿替洛尔对大鼠血压、心率的作用。 Traditional methods to observe the hemodynamic parameters of rats need to anesthetize or brake the animals, and anesthesia or brake-induced stress has a great impact on animal cardiovascular function. Arterial blood pressure was monitored during conscious and free exercise in rats, and heart rate has been reported. However, in some studies, administration was via the intravenous route. This experiment improved the method of intragastric administration, the use of gastric fistula injection, can directly observe the intragastrical administration of short-term hemodynamic changes. On this basis, we observed the effect of nitrendipine and atenolol on blood pressure and heart rate in rats.