论文部分内容阅读
血红素氧合酶1(HO-1)作为应激反应蛋白,其抗凋亡的研究成为新热点,而近年来研究表明,HO-1在眼病中起着重要的保护作用,HO-1是血红素分解代谢的限速酶,能催化血红素转化为胆绿素、一氧化碳和游离铁,均为抗凋亡的主要效应分子.就HO-1的生物学特性及其抗凋亡机制进行阐述,并分别对HO-1在角膜病、青光眼、白内障、葡萄膜炎、Graves眼病、糖尿病视网膜病变、视网膜色素变性等眼病中所起保护作用及相关机制的研究进展进行综述.“,”Heme oxygenase 1 (HO-1) is a stress response protein,and its anti-apoptosis research becomes a new hot spot.In recent years,HO-1 plays an important protective role in ophthalmopathy.HO-1 is a rate-limiting enzyme of heme catabolism,which can catalyze the transformation of heme to bilirubin,carbon monoxide and free iron.HO-1 is the main effector molecule of anti-apoptosis.The biological characteristics and anti apoptosis mechanism of HO-1 were elaborated and the research progress of H O-1 in corneal diseases,glaucoma,cataract,uveitis,Graves ophthalmopathy,diabetic retinopathy,retinitis pigmentosa and related mechanisms,which were related to anti-apoptosis,were reviewed.