κ阿片受体由３８０个氨基酸组成 ,属于Ｇ蛋白偶联受体家族 ,存在七个跨膜结构 ,强啡肽(ｄｙｎｏｒｐｈｉｎ，ＤＹＮ)是其内源性配体。κ受体参与痛觉、神经内分泌、情感行为和认知等重要的生理活动［１］。研究表明κ受体不参与吗啡镇痛和奖赏作用 ,但参与吗啡戒断反应的表达? The κ opioid receptor consists of 380 amino acids and belongs to the family of G protein-coupled receptors. There are seven transmembrane structures, and dynorphin (DYN) is its endogenous ligand. κ receptors are involved in important physiological activities such as pain, neuroendocrine, emotional behavior and cognition [1]. Studies suggest that κ receptors are not involved in morphine analgesia and reward but are involved in the expression of morphine withdrawal response.