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目的 :探讨脂质过氧化损伤水平和血清一氧化氮 (NO)浓度及其与血压的关系。方法 :随机选取一个社区 2 3～ 5 9岁人群 2 0 0例 ,按年龄分为 2 3～、30～、4 0～和 5 0～ 5 9岁 4组 ,分别进行常规体检和测定NO、超氧化物歧化酶 (SOD)和丙二醛 (MDA)活性 ,探讨上述 3个指标与高血压 (≥ 14 0 / 90mmHg ,1mmHg =0 .133kPa)之间的关系。结果 :①随年龄的增加 ,心电图和肝胆B超检查异常率均逐渐上升 ,血清总胆固醇水平随年龄增长也呈现增加趋势 ,而三酰甘油水平在 4组之间未发现明显差异 ;②随年龄的增加 ,原发性高血压 (EH)发病率上升 ,血浆NO水平逐渐下降 ,而MDA含量则呈上升趋势 ,其中血浆NO水平与EH的关系非常密切 (r =- 0 .986 ,P <0 .0 5 )。结论 :脂质过氧化损伤和血浆NO水平下降可能共同促进了EH的发生和发展
Objective: To investigate the relationship between the level of lipid peroxidation injury and serum nitric oxide (NO) and its relationship with blood pressure. Methods: A total of 200 patients from 23 to 59 years of age in community were randomly selected and divided into 4 groups according to their ages: 2 3 ~, 30 ~, 40 ~ 50 and 5 0 ~ 5 9 years old. The routine physical examination and determination of NO, (SOD) and malondialdehyde (MDA) in the serum of patients with hypertension, and to explore the relationship between the above three indexes and hypertension (≥14 0 / 90mmHg, 1mmHg = 0.133kPa). Results: ① With the increase of age, the abnormal rates of B-mode ultrasonography and hepatobiliary ultrasound examination increased gradually, serum total cholesterol level also increased with age, but no significant difference was found in the three groups; , The incidence of essential hypertension (EH) increased, the level of plasma NO decreased gradually, while the content of MDA increased. The level of plasma NO was closely related to EH (r = - 0.986, P <0 .0 5). Conclusion: The decrease of lipid peroxidation injury and plasma NO level may jointly promote the occurrence and development of EH