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目的 :探讨老年性脑梗塞患者血清中一氧化氮 (NO)浓度的含量变化。材料与方法 :选择住院病人 ,其中包括老年患者 (年龄≥ 6 5岁 )及中、青年患者 (≤ 6 4岁 )。健康体检者作对照组 ,标本采集及保存均为晨空腹静脉采血 ,常规分离血清 ,当天检测或置于 - 2 0℃保存待测血清NO-2 /NO-3 浓度 ,参照Cortas并加改进 ,以系列亚硝酸钠作标准对照。间接反应体内NO水平。结果 :梗塞及各年龄组病人血清NO-3 水平测定结果显示 :急性脑梗塞组明显低于健康组。年龄≥ 6 5岁明显低于≤ 6 4岁组。结论 :通过本临床研究 ,进一步提示NO在脑梗塞的发病中起一定作用 ,有可能为临床观察血管内皮功能 ,预测老年性脑梗塞发生的危险性提供依据。
Objective: To investigate the changes of serum nitric oxide (NO) concentration in patients with senile cerebral infarction. MATERIALS AND METHODS: Inpatients were selected, including elderly patients (≥65 years) and middle-aged and young patients (≤64 years). Healthy subjects were taken as the control group. Samples were collected and stored for morning fasting venous blood. The serum was separated routinely. The serum concentration of NO-2 / NO-3 was measured at -20 ℃ overnight, A series of sodium nitrite as a standard control. Indirect NO level in vivo. Results: The levels of serum NO-3 in patients with infarction and all age groups showed that the acute cerebral infarction group was significantly lower than the healthy group. Age> 6 5 years old was significantly lower than ≤ 6 4 years old group. Conclusion: This clinical study further suggests that NO plays a role in the pathogenesis of cerebral infarction and may provide the basis for clinical observation of vascular endothelial function and prediction of the risk of senile cerebral infarction.