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目的:探讨pRb2/P130与CDK4蛋白表达与子宫内膜癌的发生、发展的关系。方法:应用免疫组化S-P法检测pRb2/P130、CDK4在28例正常增生期子宫内膜组织、20例不典型增生子宫内膜、30例子宫内膜腺癌组织中的表达程度,并分析它们之间的关系。结果:pRb2/P130蛋白在正常增生期子宫内膜、不典型增生子宫内膜、子宫内膜腺癌组织中的阳性表达率依次递减,而CDK4的阳性表达率依次递增,子宫内膜腺癌和不典型性增生中pRb2/P130阳性表达率明显低于正常增生期子宫内膜,差异均有统计学意义(P<0.05),而CDK4的阳性表达率明显高于正常增生期子宫内膜,差异均有统计学意义(P<0.05)。pRb2/P130阳性表达缺失与组织学分级有关(P<0.05),与子宫肌层浸润程度无关(P>0.05);CDK4阳性表达与子宫内膜腺癌肌层浸润深度有关(P<0.05),而与肿瘤的组织学分级和临床分期无关(P>0.05)。pRb2/P130蛋白表达与CDK4呈负相关(P<0.05)。结论:子宫内膜腺癌中存在pRb2/P130蛋白表达下降或缺失及CDK4的异常表达,促进了细胞的生长和肿瘤的发展,是子宫内膜腺癌的发生、发展中的重要事件。
Objective: To investigate the relationship between the expression of pRb2 / P130 and CDK4 and the occurrence and development of endometrial carcinoma. Methods: The expression of pRb2 / P130 and CDK4 in 28 cases of normal proliferative endometrium, 20 cases of atypical hyperplasia endometrium and 30 cases of endometrial adenocarcinoma were detected by immunohistochemical SP method. The relationship between. Results: The positive expression rates of pRb2 / P130 protein in normal proliferative endometrium, atypical hyperplasia endometrium and endometrial adenocarcinoma decreased in turn, while the positive expression rate of CDK4 increased in turn, the expression of endometrial adenocarcinoma and The expression of pRb2 / P130 in atypical hyperplasia was significantly lower than that in normal proliferative endometrium (P <0.05), but the positive expression rate of CDK4 was significantly higher than that in normal proliferative endometrium All were statistically significant (P <0.05). The loss of pRb2 / P130 expression was related to the histological grade (P <0.05), but not to the degree of myometrial invasion (P> 0.05). The positive expression of CDK4 correlated with the depth of myometrial invasion in endometrial adenocarcinoma (P <0.05) But not with histological grade and clinical stage (P> 0.05). The expression of pRb2 / P130 protein was negatively correlated with CDK4 (P <0.05). CONCLUSION: The decrease or deletion of pRb2 / P130 protein expression and the abnormal expression of CDK4 in endometrial adenocarcinoma promote the cell growth and tumor development, which is an important event in the development of endometrial adenocarcinoma.