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在人类维生素H是羧酶反应的一个重要辅酶。食物缺乏维生素H是罕见的,能产生脂溢性皮炎和秃发。先天性有机酸代谢缺陷的患者、丙酸血症和β-甲基巴豆酰甘氨酸尿症,对维生素H有良好反应。本文报告1例病儿其皮肤病变具有维生素H缺乏的特征,且发生神经系统异常,符合有机酸紊乱。病例报告:患儿男性,正常妊娠足月出生,出生体重2.95kg,双亲健康非近亲婚配,无家族史。患儿在10个月内发育正常。能扶持站立和说一、二个单词。由于皮疹、鼻粘膜发炎、眼睑炎、秃发、坐不稳,全身张力过低,头下垂而就诊。最初诊断为肠病性肢皮炎,血清锌中度降低。用硫酸锌50mg/日治
In humans, vitamin H is an important coenzyme in the carboxylase reaction. Lack of vitamin H in foods is rare and produces seborrheic dermatitis and baldness. Patients with congenital organic acid metabolism deficiency, propionatemia and β-methyl crotonyl glycineuria, have good response to vitamin H. This article reports a case of sick children with skin lesions characterized by vitamin H deficiency, and the occurrence of nervous system abnormalities, in line with organic acid disorders. Case Reports: Children with children born at term full-term pregnancy, birth weight 2.95kg, non-married relatives of parents with unmarried, no family history. Children develop normally within 10 months. Can stand up and say one or two words. Due to rash, inflammation of the nasal mucosa, blepharitis, alopecia, sitting unsteady, generalized tension, head drooping and treatment. Initial diagnosis of enteropathic dermatitis, serum zinc moderate decrease. Treatment with zinc sulfate 50mg / day