目的　为镉的雄性生殖毒性评价筛选出敏感指标 ,以便对其生殖毒性进行早期监测。方法　应用氯化镉对成年雄性SD大鼠进行腹腔染毒 (连续 7d) ,染毒剂量分别为 0 .2、0 .4、0 .8mg/kg体重 (以镉计 )。对大鼠进行睾丸精子头计数 ,并计算每日精子生成量。应用计算机辅助精子分析(CASA)系统对附睾尾精子运动能力进行检测。结果　 0 .8mg/kg染镉组大鼠睾丸精子头计数和每日精子生成量为 (16 .45± 3 .0 1) 10 6/g和(2 .6 5± 0 .5 1) 10 6·d-1·g-1,比对照组 [(119.2 0± 14.5 1) 10 6/g和(19.5 1± 2 .37) 10 6·d-1·g-1]明显降低 ,0 .2mg/kg染镉组大鼠附睾尾精子曲线运动速度 (VCL)即明显降低 ,0 .4mg/kg染镉组大鼠精子运动能力的改变更为显著 ,差异均有显著性 (P <0 .0 5或P <0 .0 1)。 0 .8mg/kg染镉组未见活动精子。结论　精子运动参数是镉雄性生殖毒性评价较敏感的观察指标 ,CASA系统是雄性生殖毒理学研究的有力工具 Aim To screen sensitive indicators for the evaluation of male reproductive toxicity of cadmium in order to monitor their reproductive toxicity early. Methods Adult cadavers (SD rats) were treated intraperitoneally with cadmium chloride (intraperitoneally for 7 days) with doses of 0.2, 0.4, 0.8 mg / kg body weight (cadmium). Testicular sperm counts were performed on rats and daily sperm production was calculated. The sperm motility of epididymal tails was detected by computer assisted sperm analysis (CASA) system. Results The sperm count and daily sperm production of testis at 0 .8 mg / kg cadmium were (16.45 ± 3.01) 10 6 / g and (2.56 ± 0.51) 10 6 · D-1 · g-1 was significantly lower than that of the control group [(119.2 ± 14.5 1) 10 6 / g and (19.5 1 ± 2.37) 10 6 · d -1 · g -1] kg / kg cadmium significantly decreased the sperm motility (VCL) in the tail of the epididymis, and the change of the sperm motility in the group of 0.4 mg / kg cadmium was more significant (P <0. 0 5 or P <0 .0 1). 0 .8mg / kg cadmium group showed no active sperm. Conclusions Sperm motility parameters are more sensitive indicators for the evaluation of male reproductive toxicity of cadmium, and the CASA system is a powerful tool for the study of male reproductive toxicology