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本文报告头孢三嗪与妥布拉霉素对绿脓杆菌10118超微结构的影响.头孢三嗪在2MIC浓度主要使菌体末端膨出并出现丝状体;在20MIC主要显示胞内损害.妥布拉霉素在2MIC则主要致胞内损害;20MIC致胞壁破损,胞内容物溢出.两药合用在较小剂量即可使菌体成多型性改变,胞壁、胞浆均严重损害.
This article reports the effect of cefotaxime and tobramycin on the ultrastructure of Pseudomonas aeruginosa 10118. Ceftriaxone mainly causes the end of the cell to bulge and appear filaments at 2MIC concentration; Bacillus subtilis in 2MIC is mainly caused by intracellular damage; 20MIC caused cell wall damage, intracellular contents overflow. Combined use of two drugs in a smaller dose can make the cell into a polymorphic change, cell wall, cytoplasm are severely damaged .