Objective:To investigate the socio-cultural factors that contribute to Matal Mortality in Edo South Senatorial District. Methods:The population of the study was made up of 2 157 females of reproductive age and multi-stage random sampling technique was used. The instrument for data collection was a self developed structured and validated questionnaire with a reliability of 0.82. Focus group discussion (FGD) and in-depth interview guide were employed to complement the instrument. Inferential statistics of multiple regressions were also employed to test the hypotheses at 0.05 level of significance. Results:The results showed that the socio-cultural variables when taken together contributed positively to matal mortality [R2=0.32;CV=16.5;df=7). The finding further revealed that six, out of seven of the independent variables in the study significantly contributed to matal mortality in Edo South Senatorial District. The implications of these findings in matal and child health care were highlighted. Conclusions:The study had shown that in addition to medical causes of matal mortality, there are socio-cultural factors that contribute to women dying during pregnancy, labour and pueperium.