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作者用伤寒“O”抗原免疫家兔,并分别于不同时间注入植物血凝素(PHA)。用凝集反应测定各组家兔血清抗体滴度,用镜检法测外周血的淋转率。结果显示:抗原加PHA后,抗体滴度的几何均数最高(4.310±0.399,P<0.05);淋转率也明显升高,与对照组比较,两者间呈正相关(r=0.5329,P<0.01)表明PHA与抗原同时注射,可以增强免疫应答,故可作为一种安全有效的免疫增强剂,也是一种有希望的新的免疫佐剂。
The authors immunized rabbits with typhoid “O” antigen and injected phytohemagglutinin (PHA) at different times. The agglutination reaction was used to measure the serum antibody titers of rabbits in each group, and the rate of lymph node metastasis was detected by microscopy. The results showed that the geometric mean of antibody titers was the highest (4.310 ± 0.399, P <0.05) after the addition of antigen and PHA, and the lymph node metastasis rate was significantly increased as compared with the control group (r = 0.5329, P <0.01) showed that simultaneous injection of PHA and antigen can enhance the immune response, so it can be used as a safe and effective immune enhancer and a promising new immune adjuvant.