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目的探讨碘过量对实验性自身免疫性甲状腺炎(Experiment autoimmune thyroiditis,EAT)大鼠血脂的影响及不同硒水平的干预作用。方法雌性Lewis大鼠随机分为对照、造模、造模+高碘补硒、造模+高碘适硒、造模+高碘低硒组。猪甲状腺球蛋白免疫建立EAT模型。检查大鼠甲状腺病理改变,测定各组甲状腺自身抗体、甲状腺激素及血脂水平。结果各组甲状腺自身抗体及甲状腺激素水平均明显高于对照组;造模组甘油三酯(TG)水平(1.09±0.29)mmol/L明显低于对照组(1.93±0.59)mmol/L,高密度脂蛋白胆固醇(HDL-C)水平(1.23±0.12)mmol/L则明显高于对照组(0.93±0.21)mmol/L;造模+高碘适硒组总胆固醇(TC)水平(2.36±0.24)mmol/L及低密度脂蛋白胆固醇(LDL-C)水平(0.92±0.21)mmol/L均明显低于造模组(2.87±0.10),(1.42±0.15)mmol/L;相同高碘水平下,血脂水平随着补硒量的减少呈上升趋势。结论大鼠在EAT及碘过量伴EAT时有血脂代谢紊乱,相同高碘水平下低硒时加重甲状腺的炎症破坏并伴有血脂的升高。
Objective To investigate the effect of iodine excess on serum lipids in rats with experimental autoimmune thyroiditis (EAT) and the effect of different levels of selenium. Methods Female Lewis rats were randomly divided into control, modeling, modeling + high iodine selenium, modeling + high iodine suitable selenium, modeling + high iodine selenium group. Pig thyroglobulin immunization established EAT model. The pathological changes of thyroid in rats were examined. Thyroid autoantibodies, thyroid hormones and blood lipids were measured in each group. Results The levels of thyroid autoantibodies and thyroid hormones in each group were significantly higher than those in the control group. The levels of triglyceride (TG) in the model group (1.09 ± 0.29) mmol / L were significantly lower than those in the control group (1.93 ± 0.59) mmol / L The level of HDL-C (1.23 ± 0.12) mmol / L was significantly higher than that of the control group (0.93 ± 0.21) mmol / L and the total cholesterol (TC) 0.24 mmol / L and LDL-C levels (0.92 ± 0.21) mmol / L were significantly lower than those in model group (2.87 ± 0.10) and (1.42 ± 0.15) mmol / L, Levels, blood lipid levels increased with the reduction of selenium levels. Conclusions Rats with dyslipidemia in EAT and iodine excess with EAT may exacerbate the inflammatory destruction of the thyroid gland with the increase of blood lipids in the same high iodine levels.