急性T淋巴细胞白血病(T-ALL)以外周血高白细胞计数、原始细胞比例高为主要特征,易发生胸膜渗出、中枢神经系统浸润及纵膈肿瘤,病情较凶险,进展快,预后欠佳。目前T-ALL采用标准的化疗方案能获得较高的完全缓解(CR)率,但T-ALL患者的长期生存率较低,尤其是对化疗药物耐药、CR后复发的患者预后较差,因此阐明T-ALL的发病机 Acute T-lymphoblastic leukemia (T-ALL) in peripheral blood high white blood cell count, the high proportion of blast cells as the main features prone to pleural effusion, central nervous system invasion and mediastinal tumors, the disease is more dangerous, rapid progress, poor prognosis . At present, T-ALL adopts standard chemotherapy regimen to achieve a high complete remission (CR) rate. However, the long-term survival rate of T-ALL patients is low, especially for chemotherapeutic drugs. Patients with recurrent CR have a poor prognosis, Therefore elucidate the pathogenesis of T-ALL