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目的 :探索抗淋巴细胞球蛋白 (ALG)的合理使用方案。方法 :随机选择肾移植患者 60例 ,根据使用 AL G的时间不同分两组 ,观察病人外周血 CD3+细胞数变化 ,急性排斥反应及并发症发生率。结果 :两组病人急性排斥反应率 ,术后 5天内 CD3+细胞数无统计学差异 ,但 B组 (AL G30 0 mg/ d,7天以上 )的巨细胞病毒病及一般感染率明显高于 A组 (ALG30 0 mg/ d,3～ 6天 )。结论 :术后连续 3～ 6天使用常规剂量 AL G是一种有效 ,安全价廉的免疫抑制方案。
Objective: To explore the rational use of anti-lymphocyte globulin (ALG). Methods: Sixty renal transplant recipients were randomly selected. The time course of ALG was divided into two groups. The number of CD3 + cells, the number of acute rejection and the incidence of complications were observed. Results: There was no significant difference in the number of CD3 + cells within 5 days after operation in both groups, but the cytomegalovirus disease and general infection rate in group B (AL G30 0 mg / d, 7 days) were significantly higher than those in group A Group (ALG30 0 mg / d, 3 to 6 days). CONCLUSION: Using conventional dose of AL G for 3 ~ 6 consecutive days after operation is an effective and safe immunosuppressive regimen.