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观察重组人纤维结合素多肽CH5 0对化疗小鼠巨噬细胞的影响。结果表明 ,腹腔连续注射CH5 0能防止化疗药物使外周血单核细胞数量和腹腔细胞的数量降低 ,能促进代谢活性、杀瘤活性、细胞因子分泌及脾淋巴细胞的增殖反应。提示CH5 0可提高肿瘤化疗药物的疗效。
To observe the effect of recombinant human fibronectin polypeptide CH5 0 on murine macrophages. The results showed that continuous intraperitoneal injection of CH5 0 can prevent chemotherapy drugs to reduce the number of peripheral blood mononuclear cells and the number of peritoneal cells, and promote metabolic activity, tumor-killing activity, cytokine secretion and spleen lymphocyte proliferation reaction. Tip CH50 can improve the efficacy of chemotherapy drugs.