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顺氯胺铂(cis platinum diamminedicbloride,DDP或PDD)是铂的无机螯合物,简称顺铂,是目前临床上常用的广谱抗肿瘤药物之一。本品为黄色粉末状结晶,溶于二甲基酰胺,不溶于一般有机溶媒;可部分溶于水,且可随水温的增高而增溶性质不稳定,将其水溶液放置在室温中一定时间后即可变色,析出沉淀,转化为无抑瘤作用的反式结构并发生水解而失效。为避免分解,需放于阴暗处避光保存。顺铂主要对泌尿生殖系的膀胱、睾丸、卵巢、宫颈等处的恶性肿瘤及头颈部癌有效,亦可用于身体其他部位的肿瘤。其主要毒副作用有:(1)消化道反应,表现为食欲减退、恶心呕吐、腹泻;(2)
Cisplatin (cisplatin diamminedicbloride, DDP or PDD) is a platinum inorganic chelate, referred to as cisplatin, is currently widely used in clinical broad-spectrum anti-tumor drugs. This product is a yellow powder crystal, soluble in dimethyl amide, insoluble in general organic solvents; can be partially soluble in water, and with the increase of water temperature and solubilization instability, the aqueous solution was placed in room temperature for a certain period of time You can change color, precipitate precipitation, trans-no anti-tumor effect into the trans structure and hydrolysis and failure. To avoid decomposition, it is necessary to keep it in the shade to avoid light. Cisplatin is mainly effective on malignant tumors of the genitourinary bladder, testes, ovaries, cervix, and head and neck cancer as well as on tumors in other parts of the body. Its main side effects are: (1) digestive tract reactions, manifested as loss of appetite, nausea and vomiting, diarrhea; (2)