为了探讨动脉瘤的病因以及研究新的栓塞材料,必须建立可靠的动脉瘤模型。动脉瘤模型的建立方法很多,有病因诱导法、血管移植法、动脉局部结构破坏法、弹性蛋白酶诱导法等。除了传统的梭形和囊形,近年亦出现了巨大、复杂以及分叉部的动脉瘤模型,且在形态、血流动力学以及组织学特征上更趋于人类自然发生的动脉瘤。本文回顾各种动脉瘤模型的建立方法,并阐明各种模型的优缺点及应用进展。 In order to investigate the etiology of aneurysms and to study new embolic materials, a reliable aneurysm model has to be established. There are many ways to establish the aneurysm model, including etiology induction, vascular transplantation, arterial local structure destruction, elastase induction and so on. In addition to the traditional fusiform and sacs, aneurysm models of huge, complex, and bifurcation segments have also emerged in recent years and are more apt to occur naturally in humans as morphologically, hemodynamically and histologically. This paper reviews the establishment of various aneurysm models, and illustrates the advantages and disadvantages of various models and their applications.