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目的:考察丹参注射液与3种代糖溶媒(果糖注射液、转化糖注射液和转化糖电解质注射液)配伍的稳定性,旨在为糖尿病患者的临床用药提供参考。方法:按临床用药的最大使用量(20 m L·次-1),制备丹参注射液与3种代糖溶媒(果糖注射液、转化糖注射液和转化糖电解质注射液)的配伍溶液,考察配伍溶液的外观、p H、不溶性微粒、含量测定、紫外光谱及最大吸收波长。结果:在5 h内,溶液性状、不溶性微粒、含量、紫外光谱及最大吸收波长均无显著变化,p H在正常范围(3.5~5.5)内略有变化,且1~2 h内各项数据变化最小,最为稳定。结论:丹参注射液与3种代糖溶媒配伍后,溶液在5 h内基本稳定,建议配伍静置1 h后再输注,以提高输液的安全性。
OBJECTIVE: To investigate the stability of Salvia miltiorrhiza injection combined with three kinds of sugar substitute vehicles (fructose injection, invert sugar injection and transfusion sugar electrolyte injection) to provide reference for the clinical use of diabetes mellitus patients. Methods: The compatibility of Salvia miltiorrhiza injection with three kinds of glucose-modified vehicles (fructose injection, invert sugar injection and invert sugar electrolyte injection) was prepared according to the maximum dose of clinical medication (20 m L · s -1) The appearance of the compatibility solution, p H, insoluble particles, determination of content, UV spectrum and maximum absorption wavelength. Results: Within 5 h, no significant changes were observed in solution properties, insoluble particulates, UV-vis spectra and maximum absorption wavelength. The values of p H varied slightly within the normal range (3.5-5.5) and all the data within 1-2 h Change the smallest, most stable. Conclusion: Salvia miltiorrhiza injection and three kinds of sugar substitutes, the solution within 5 h basically stable, it is recommended compatibility 1 h before infusion, to improve the safety of infusion.