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目的观察动脉粥样硬化性脑梗死(ACI)患者血清氧化低密度脂蛋白(ox-LDL)、C反应蛋白(CRP)、金属基质蛋白-9(MMP-9)水平与颈动脉内中膜厚度及斑块稳定性的关系。方法选取动脉粥样硬化性脑梗死患者110例为A组,腔隙性脑梗死(LACI)患者90例为B组,100例健康人群为C组,用酶联免疫吸附试验(ELISA)法检测血清ox-LDL,CRP和MMP-9水平,并检测颈动脉内中膜厚度及斑块形成情况。结果 A、B组患者血清ox-LDL、CRP、MMP-9水平、颈动脉内中膜厚度及颈动脉斑块检出率显著高于C组(P<0.05)。血清ox-LDL,CRP、MMP-9及吸烟是脑梗死患者颈动脉斑块形成的独立危险因素(P<0.05)。脑梗死患者中无斑块组、稳定性斑块组及不稳定斑块组血清ox-LDL,CRP、MMP-9水平依次升高(P<0.05)。结论脑梗死患者血清ox-LDL,CRP和MMP-9水平升高与颈动脉内中膜增厚、斑块形成及稳定性密切相关。
Objective To observe the changes of the levels of serum ox-LDL, C-reactive protein (CRP), matrix metalloproteinase-9 (MMP-9) and carotid intima-media thickness in patients with atherosclerotic cerebral infarction And plaque stability of the relationship. Methods One hundred and ten patients with atherosclerotic cerebral infarction were selected as group A, 90 patients with lacunar infarction (LACI) as group B and 100 healthy subjects as group C. Serum levels were determined by enzyme linked immunosorbent assay (ELISA) Serum levels of ox-LDL, CRP and MMP-9 were measured and carotid intima-media thickness and plaque formation were measured. Results The levels of serum ox-LDL, CRP, MMP-9, intima-media thickness and carotid plaque in group A and group B were significantly higher than those in group C (P <0.05). Serum levels of ox-LDL, CRP, MMP-9 and smoking were independent risk factors for carotid plaque formation in patients with cerebral infarction (P <0.05). Serum levels of ox-LDL, CRP and MMP-9 in non-plaque group, stable plaque group and unstable plaque group increased in turn (P <0.05). Conclusion The elevated serum levels of ox-LDL, CRP and MMP-9 in patients with cerebral infarction are closely related to the intima-media thickness, plaque formation and stability in carotid artery.