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目的:了解乙肝表面抗原阴性(HBsAg阴性)母亲及其婴儿乙肝疫苗接种情况及抗-HBs滴度水平,从而为今后针对该特殊人群进行更好的乙肝疫苗免疫策略提供依据。方法:2010年5月～2010年10月,对陕西省227对HBsAg阴性母亲及其婴幼儿(月龄为8～24月)进行流行病学调查并采集血液标本,对母婴血清抗-HBs进行定性及定量检测。结果:母亲乙肝表面抗体(抗-HBs)阳性率为45.4%,抗-HBs平均滴度为12.88 mIU/mL(95%CI:8.91-18.19)。婴儿乙肝疫苗首针、第二针和第三针的及时接种率分别为95.2%,93.8%和85.9%。婴儿抗-HBs阳性率为77.1%,抗-HBs平均滴度为37.15 mIU/mL(95%CI:28.18-48.98)。结论:婴儿乙肝疫苗首针及时接种率较高,但三针全程及时接种率仍需提高。母亲抗-HBs阳性率较低,应当重视HBsAg阴性孕龄妇女的乙肝疫苗接种及乙肝标志物的检测,从而提高该人群的乙肝免疫水平。
OBJECTIVE: To understand the status of hepatitis B vaccination and anti-HBs titer in hepatitis B surface antigen-negative (HBsAg-negative) mothers and their infants, so as to provide a basis for better hepatitis B vaccine immunization strategies for this particular population in the future. Methods: From May 2010 to October 2010, 227 HBsAg negative mothers and their infants (aged 8-24 months) in Shaanxi Province were investigated by epidemiology and blood samples were collected for the detection of anti-HBs Qualitative and quantitative testing. Results: The positive rate of hepatitis B surface antibody (anti-HBs) in mothers was 45.4% and the average titer of anti-HBs was 12.88 mIU / mL (95% CI: 8.91-18.19). The timely vaccination rates of the first, second and third needles of infant hepatitis B vaccine were 95.2%, 93.8% and 85.9% respectively. The positive rate of anti-HBs in infants was 77.1% and the average anti-HBs titer was 37.15 mIU / mL (95% CI: 28.18-48.98). Conclusion: The first vaccination of hepatitis B vaccine in infants is timely, but the timely vaccination rate of three needles still needs to be improved. Maternal anti-HBs positive rate is low, should pay attention to HBsAg negative gestational age women’s hepatitis B vaccination and detection of hepatitis B markers to improve the population of hepatitis B immunity.