论文部分内容阅读
柳氮磺吡啶(SASP)栓经直肠给药治疗大鼠溃疡性结肠炎3周,见结肠粘膜出血、糜烂溃疡病变点数较阴性对照组明显减少。病理检查见粘膜的弥漫性炎症消失或减轻,充血、水肿以及肠腺和固有膜间的炎细胞浸润消失或明显减轻。坏死的上皮和腺体以及糜烂溃疡面已修复,肠腺的杯状细胞显著增加。疗效优于同剂量灌胃给药。
Sulfasalazine (SASP) suppository was administered to rectum for 3 weeks in rats with ulcerative colitis. Hemorrhage of colonic mucosa and lesion site of erosion and ulcer were significantly reduced compared with negative control group. Pathological examination showed diffuse mucosal inflammation disappeared or reduced, congestion, edema and glandular and intrinsic membranous inflammatory cell infiltration disappeared or significantly reduced. Necrosis of the epithelium and glands and erosion of the ulcer surface has been repaired, glandular goblet cells increased significantly. The effect is better than the same dose intragastric administration.