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系统性硬化病(SSc)是一种累及多系统的疾病,属于自身免疫性疾病,病因和发病机制尚不清楚,迄今尚无有效的方法能够阻止SSc疾病进展、逆转皮肤及内脏器官纤维化。传统治疗采用免疫抑制剂,虽然在早期能够改善病情,但对于进展性弥漫性的SSc疗效较差。自体造血干细胞移植术治疗重症SSc患者,Ⅰ和Ⅱ期临床研究证明其能够有效改善皮肤硬化、增厚,且能够稳定内脏器官的功能,延缓疾病的进展,防止复发,疗效较稳定。
Systemic Sclerosis (SSc) is a multi-systemic disease and belongs to the autoimmune diseases. The etiology and pathogenesis of SSc is not yet clear. So far there is no effective way to stop the progression of SSc disease and reverse the fibrosis of the skin and internal organs. The traditional treatment of immunosuppressive agents, although early to improve the condition, but poor progress for diffuse SSc. Autologous hematopoietic stem cell transplantation for severe SSc patients, Ⅰ and Ⅱ clinical studies have shown that it can effectively improve the skin sclerosis, thickening, and can stabilize the function of internal organs, delay the progression of the disease, prevent recurrence, the effect is more stable.