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目的：研究口服大承气汤或大黄对小鼠抗菌能力的影响。方法：于建立细菌性腹膜炎模型前分别口服大承气汤或大黄对小鼠预防治疗２ｄ后，分别腹腔注射大肠杆菌（１０８／ｍｌ）或变形杆菌（１０６／ｍｌ）建立腹膜炎模型，再继续用药治疗２ｄ。结果：模型的治疗组小鼠死亡数及相应菌血症发生率明显低于对照组（Ｐ＜０．０５），并且有剂量依赖性。大承气汤和大黄对大肠杆菌和变形杆菌感染的小鼠均有良好保护作用。预防加治疗组和模型组治疗后存活鼠心脏血涂片、血培养细菌呈阴性，而死亡鼠呈阳性。结论：大承气汤及大黄有良好的抗菌作用
Objective: To study the effect of oral Dachengqi Decoction or rhubarb on the antibacterial activity of mice. METHODS: Before the establishment of a bacterial peritonitis model, Dachengqi Decoction or rhubarb was orally administered to mice for 2 days, and then peritonitis models were established by intraperitoneal injection of Escherichia coli (108/ml) or Proteus (106/ml), and continued medication. Treatment 2d. Results: The number of deaths and the incidence of bacteremia in the treated group were significantly lower than those in the control group (P<0.05), and were dose-dependent. Dachengqi Decoction and Rhubarb have good protective effects on E. coli and Proteus-infected mice. Survival rat heart blood smears and blood culture bacteria were negative in the treatment plus treatment group and model group, while death mice were positive. Conclusion: Dachengqi Decoction and Rhubarb have good antibacterial effect