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目的:考察醋酸地塞米松纳米脂质载体温敏型原位凝胶的在体消除情况。方法:应用γ-闪烁照相技术,在10min内动态采集含醋酸地塞米松的PBS滴眼剂、纳米脂质载体及纳米脂质载体原位凝胶制剂在体消除数据,绘制消除曲线。结果:在动态采集10min后,醋酸地塞米松PBS滴眼剂,纳米脂质载体和纳米脂质载体原位凝胶制剂在角膜表面分别残余8.75%、37.08%及75.4%的放射活性。结论:醋酸地塞米松纳米脂质载体温敏型原位凝胶具有更好的眼部滞留性和更高的生物利用度。
OBJECTIVE: To investigate in vivo elimination of temperature-sensitive in situ gels of dexamethasone acetate nano-lipid carriers. Methods: The γ-scintigraphy technique was used to dynamically remove the data in vivo by using PBS eye drops containing dexamethasone acetate, nano-lipid carrier and nano-lipid carrier gel in 10min to draw the elimination curve. RESULTS: Dexamethasone acetate eyedrops, nano-lipid and nano-lipid carrier in-situ gel formulations retained radioactivity of 8.75%, 37.08% and 75.4% on the corneal surface after 10 min dynamic acquisition. CONCLUSION: Dexamethasone acetate nanoliposomes thermo-sensitive in situ gels have better ocular retention and higher bioavailability.