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血清素(5—羟色胺)是新近发现的激素,它是体内极为重要的神经内分泌液递因子,是维持机体正常活动的重要物质。血清素的前身是色氨酸,其最终代谢产物5—羟吲哚醋酸(简称5—HIAA)由尿液排出。测定尿中5—HIAA的排量对了解血清素有关的生理和病理状态具有重要的意义。近年来已经证明血清素是血管的活性物质,但对血压的作用还不十分明确,某些降压药物的机制可能与血清素有关。为此我们对高血压病患者尿中5—HIAA的排量作了测定,并观察了经利血平治疗与促腎上腺皮质激素兴奋后的改变。材料与方法正常人30名,男、女各15名。年龄自18～
Serotonin (serotonin) is a newly discovered hormone that is a very important neuroendocrine fluid delivery factor in the body and is an important substance to maintain the normal body’s activity. Serotonin is the predecessor of tryptophan, the final metabolite 5-hydroxyindole acetic acid (referred to as 5-HIAA) excreted by the urine. Determining urinary 5-HIAA clearance is of great importance for understanding the physiological and pathological conditions associated with serotonin. In recent years, it has been proved that serotonin is the active substance of blood vessels, but its effect on blood pressure is not yet clear. The mechanism of certain antihypertensive drugs may be related to serotonin. To this end, we measured urinary 5-HIAA in patients with essential hypertension and measured the changes after stimulation with reserpine and adrenocorticotropic hormone. Materials and Methods Normal 30, male and female 15 each. Age from 18 ~