很早即发现,动物反复接触异物后,可提高动物对该异物的敏感性。认为这是由于机体接触抗原后所发生的抗原与抗体之间的反应,即免疫反应。后来进一步提出了变态反应概念,认为这是机体受到抗原刺激后所引起的异常免疫反应。引起变态反应的抗原也称作变应原,药物亦可作为变应原而引起药物变态反应或药物过敏反应。药物变态反应在临床上常见,病情轻重十分不同,但仅少数用药患者发生药物变态反应,显然这种反应的发生尚与遗传因素有关。 Very early found that animals repeatedly exposed to foreign objects, can improve the animal’s sensitivity to the foreign body. It is thought that this is due to the reaction between the antigen and the antibody that occurs after the body contacts the antigen, ie, the immune response. Later further proposed the concept of allergy, that this is the body caused by antigen stimulation after the abnormal immune response. Antigens that cause allergic reactions, also known as allergens, can also be used as allergens to cause drug allergy or drug allergy. Drug allergy is clinically common, the severity of the disease is very different, but only a small number of patients with drug allergy occurred, it is clear that the occurrence of this reaction is still associated with genetic factors.