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某些人体肿瘤的发生和生长与激素存在着密切的关系,因此可以用内分泌方法进行治疗。早在1896年Beatson 已应用卵巢切除使乳腺癌得到缓解,从本世纪40年代以来,肿瘤的内分泌疗法获得了较广泛的应用,但是直到70年代才可能对某些肿瘤通过生化测定预测内分泌治疗的效果。1961年Folca 给乳腺癌患者注入[~3H]标记的己烯雌酚(~3H-hexestrol),发现肿瘤摄取雌激素多者应用肾上腺切除的效果好,反之则差。在正常组织激素受体的基础理论研究的推动下,1971年Jensen 确定一部份乳腺癌细
The occurrence and growth of certain human tumors are closely related to the presence of hormones, and therefore can be treated with endocrine methods. As early as 1896, Beatson had applied ovariectomy to relieve breast cancer. Since the 1940s, endocrine therapy of tumors has been widely used, but it was not until the 1970s that some tumors could be predicted by biochemical assays for endocrine therapy. effect. In 1961, Folca injected [~3H]-labeled diethylstilbestrol (3H-hexestrol) into breast cancer patients. It was found that tumors that ingested estrogen were more likely to have adrenalectomy, and vice versa. Driven by basic theoretical studies of hormone receptors in normal tissues, Jensen identified a portion of breast cancer in 1971