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采用微电极细胞内记录和电子计算机实时采样技术,研究了组胺致豚鼠心室乳头肌早发后去极化和触发活动。组胺(6.0μmol/L)可使动作电位APD_(50)、APD_(90)明显缩短(数据取自无异常自律性和振荡电位的细胞)。组胺可诱发早发后去极化(发生率57％),振荡电位和触发活动。早发后电位在低频驱动(0.2～1.0Hz)时易于发生且常常伴有动作电位时程的延长。触发活动可表现为快速自发性动作电位(发生率14％)。结果提示,组胺诱发的早发后去极化和触发活动可能和心性过敏反应等疾病发生的快速自律型心律失常有关。
Using microelectrode intracellular recording and computer real-time sampling technique, the depolarization and triggering activity of histamine-induced guinea pig ventricular papillary muscle were studied. Histamine (6.0μmol / L) significantly shortened the action potentials APD_ (50) and APD_ (90) (data were taken from cells with no abnormal self-regulation and oscillatory potential). Histamine induced depolarization after early onset (57% incidence), oscillatory potential and triggering activity. Early post-electric potential during low-frequency drive (0.2 ~ 1.0Hz) prone to occur and often accompanied by an extension of the action potential duration. Triggered activity can be expressed as a rapid spontaneous action potential (the incidence of 14%). The results suggest that histamine-induced premature depolarization and triggering activity may be associated with rapid and self-paced arrhythmias such as cardiac anaphylaxis.